Increased risk of seizures patients w/ epilepsy, history of seizures or in those w/ recognized risk for seizure; in combination w/ SSRIs, antidepressants or anorectics, TCAs & other tricyclic compounds eg, cyclobenzapine, promethazine) or opioids, MAOIs, neuroleptics or other drugs that reduce seizure's threshold. Anaphylactoid reactions. Patients w/ risk of resp depression, those receiving CNS depressants, increased intra-cranial pressure or head injury. Chronic heavy alcohol abusers. W/drawal symptoms may occur w/ abrupt discontinuation. Serious skin reactions eg, acute generalized exanthematous pustulosis, SJS & TEN. Impaired renal function. Severe hepatic impairment. May impair ability to drive & use machines. Pregnancy & lactation. Childn <16 yr.
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